Abstract: Despite the use of midostaurin (MIDO) with intensive chemotherapy (ICT) as frontline treatment for Fms-like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukemia (AML), complete remission rates are close to 60% to 70%, and relapses occur in >40% of cases.Here, we studied the molecular mechanisms underlying refractory/relapsed (R/R) dise
Chitosan (CHI), a biocompatible and biodegradable polysaccharide with the ability to provide a non-protein matrix for tissue growth, is considered to be an ideal material in the biomedical field.However, the lack of good mechanical properties limits its applications.In order to overcome this drawback, CHI has been combined with different polymers a
The subject of the study is the definition of the sources of the articles of the Siberian chronicle code (beginning with its early edition – the Kniga Zapisnaya, or the Registry Book) dedicated to the emergence of the Kuznetsk and Yenisei stockade settlements.The purpose of the paper is to compare chronicle news in the context of the narrative of
Introduction: Mastocytosis is a rare hematologic neoplasm Firearm Accessories characterized by the abnormal proliferation and accumulation of mast cells in various tissues.Its clinical manifestations vary widely, ranging from cutaneous lesions to systemic involvement with potentially life-threatening symptoms.Understanding the pathophysiology, diag